Spherical agglomeration thesis

The second goal was the development of new crystallization techniques. Two different projects were researched to progress towards this goal.

Use of talc beads as coating substrates [Masters thesis], Kolhapur: Abstract In this paper, differences in porosity, compressive strength and tablet- forming ability of carbamazepine crystals agglomerated under similar condition, but subjected to different drying temperatures are reported.

Indian J Pharm Sci ; J Pharm Sci ; Effect on crystal properties.

Drying, Agglomerates, Carbamazepine, Tabletting Introduction Agglomeration in liquid systems with a wide range of objectives including separation of colloidal particles from a liquid, spherical granulation, removal and recovery of fine solids from liquid wastes, and selective separation Spherical agglomeration thesis some components in a mixture of particles has gained increasing attention in recent years due to its relative simplicity and ease of operation 1.

The weight loss on drying was determined by removing the particles from the drying condition to an analytical balance at given time intervals.

Int J Pharm ; Spherical crystallization as a novel particle design technique for oral drug delivery system. The strength and compaction of millispheres: Optimization of the processing parameters for the preparation of granulated talc.

Finally, water-in-oil emulsions were used to make composite spherical agglomerates with two components: Through a relationship with particle porosity, the drying rate also affected the ability of particles to form tablets.

Effect of size and density. The generated composite agglomerates were relatively monodisperse and were characterized using optical microscopy, scanning electron microscopy, x-ray powder diffraction, and differential scanning calorimetry. J Pharm Pharmacol ; The first process was an anti-solvent crystallization of an intermediate.

Design and evaluation of deformable talc agglomerates prepared by crystallo-co-agglomeration technique for generating heterogeneous matrix.

Lin K, Peck GE. Am J Drug Deliv ;3: Ho T, Hersey JA. Experimental Methods The agglomeration procedure used in this study was similar to the one that reported previously This study represents a contribution in this context.

A novel process to obtain ibuprofen-paracetamol agglomerates. Cocrystal formation during cogrinding and storage is mediated by amorphous phase. Chin Pharm J ; Some spray -dried formulations of sulfaethylthiadiazole for prolonged-release medication.

Drying was continued until the weight of the particles was constant with time. Melt sonocrystallisation of ibuprofen: Investigating the gastric emptying of different sizes of non- disintegrating tablets in humans using gamma scintigraphy.

Chem Pharm Bull Tokyo ; Evaluation of fluidized bed granulation parameters on the physical properties of agglomerated talc. A solution of 0. Two continuous crystallization processes were developed as part of a demonstration unit for continuous manufacturing of Aliskiren hemifumarate.

Coating of multiparticulates for sustained release. Improved dissolution rate of indomethacin by adsorbents. Effect of processing variables on particles obtained by extrusion-spheronisation processing. Aerger JS, Price R. Processing of spherical crystalline particles via a novel solution atomisation and xtallisation by sonication SAXS technique.The agglomeration procedure used in this study was similar to the one that reported previously.

A solution of g of carbamazepine in 10 mL of ethanol was poured into 84 mL of water at 25 o C under stirring at rpm. Crystallo-co-agglomeration (CCA) is a novel particle engineering/design technique developed by Kadam et al, to overcome the limitations of spherical crystallization (SC).

Basically, it’s single step process used for size enlargement of single, two or more, small dose or large dose drugs, in combination with or without diluent. Spherical agglomeration technique is a specialized and modern method which has been successfully employed to improve flowability, packability, Compressibility, wettability, solubility, and bioavailability of various poorly soluble and poorly Compressible drugs.

Spherical agglomeration process is a multiple unit process in which crystallization, resultant crystals can be designated as spherical agglomerates2.

Spherical agglomeration is a process of formation of aggregates of crystals held together by liquid bridges2.

The agglomerates are formed. Spherical agglomeration is a novel technique where larger particles are formed out of fine crystals by different crystallization methods with the help of a bridging liquid. Spherical agglomeration use has been extended to the agglomeration of several other pharmaceutical drugs.

For example, Goczo et al., (), acetylsalicylic acid, Martino et al., (), fenbufen, Kawashima et al., (), aminophylline. Spherical crystallization can be achieved by different methods. 1.

Effect of Drying Phase on the Agglomerates Prepared by Spherical Crystallization

Spherical Agglomeration (SA) 2.

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Spherical agglomeration thesis
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